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KMID : 0356619930080020171
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Journal of Korean Society of Endocrinology
1993 Volume.8 No. 2 p.171 ~ p.179
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Ovulation Induction with Combined Gonadotropin-Releasing Hormone Agonist(D-Trp6-Luteinizing Hormone-Releasing Hormone: Decapeptyl) and Gonadotropins in Women with Polysystic Ovarian Disease
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이진용
김정훈/김석현/최영민/신창재/김정구/문신용/장윤석
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Abstract
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ABSTRACT
@EN Ovulation induction in polycystic ovarian disease (PCOD) with gonadotropins results in suboptimal cycle fecundity and frequently is complicated by ovarian hyperstimulation syndrome (OHSS). The use of a gonadotropin-releasing hormone agonist
(GnRH-a)
with gonadotropin induction of ovulation may improve the therapeutic outcome.
Between May 1990 and August 1992, 23 women with PCOD underwent a total of 20 cycles of gonadotropins (human menopausal gonadotropin [hMG] or pure follicle stimulating hormone [pFSH] or hMG/pFSH) alone and 22 cycles with adjunctive GnRH-a
(decapeptyl)
treatment in this prospective randomized study. Selective oocyte retrieval was carried out in 5 cycles of 20 gonadotropins alone cycles, and 6 cycles of 22 GnRH-a with gonadotropins cycles due to excessive follicular recruitment.
Premature luteinization was seen less frequently in the GnRH-a treated cycles than in the cycles treated with gonadotropins alone. There were no significant differences between the treatments in ovarian sensitivity to gonadotropins. Pregnancy
rate
per
cycle was 40.0% (8/20) for gonadotropins alone cycles, and 45.5% (10/22) for GnRH-a with gonadotropins cycles, which were not statistically different.
We conclude that the ovarian sensitivity to gonadotropin and pregnancy rate following gonadotropin induction of ovulation in patients with PCOD are not affected by GnRH-a pretreatment. (J Kor Soc Endocrinol 8:171~179, 1993)
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KEYWORD
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